Clinical Research Associate (Senior Research Associate)
Monday 31st January 2022
Organization Case Western Reserve University (CWRU)
Title Clinical Research Associate (Senior Research Associate)
Email Address email@example.com
Department: Center for Computational Imaging and Personalized Diagnostics
Location: Wickenden Building
Supervisor Name and Title: Christina Buzzy, PhD Director of Research Operations
Working with a high degree of independence, the Clinical Research Associate will be responsible for evaluating medical annotations and applying novel machine learning and deep learning tools in digital pathology of diseases towards detection, diagnosis, prognosis as well as treatment response. The CRA will have expertise in clinical pathology preferably at the graduate level as he/she will serve as the clinical lead in the digital pathology projects ongoing in the lab. This will include expert annotations, segmentations, identification of primitives and regions of interest, providing input in hand-crafted feature learning approaches, as well as evaluating quality control of slides as well as algorithm validation and development. He/she will also be the clinical point person regarding digital pathology research projects. The CRA will communicate regularly with the research administrative team comprised of research coordinators and report to the CCIPD Director of Research Operations for project and medical annotation coordination as well as provide input on design of clinical trials.
1. Work with research associates, faculty, and graduate students in the Center to understand the research questions at hand for digital pathology annotations and for efficient tool development using novel, hand-crafted feature strategies on digital pathology slides for AI analysis and provide validation/clinical input on classifier/algorithm performance. (30%)
2. Annotate biological primitives and segment regions of interest (i.e. cancer, disease, inflammation) on digitized tissue images for AI analysis. (25%)
3. Facilitate quality control of slides for AI analysis by creating an internal pipeline for identifying artifacts, stain variations and slide preparation strategies using CCIPD-derived AI tools i.e HistoQC, QuickAnnotator, etc. (10%)
4. Ensure successful transfer of digitized pathology images from collaborators via mail or electronic methods to the CCIPD HPC. (10)%
5. Work synergistically with other research coordinator(s) and research associates to maintain a well-annotated database of pathology slides being scanned for different projects along with their corresponding clinical information linked to raw files stored on the CCIPD high performance cluster (HPC). (10%)
6. Facilitate selection of diagnostic pathology tissue slides suitable for AI analysis from tissue blocks and serve as a secondary support role for placing requests for scanning/digitalization of glass pathology slides with clinical collaborators. (8%)
7. Participate in strategy and planning meetings with the CCIPD director/principal investigator and the research administrative team to support research operations. (7%)
Perform other duties as assigned.
Department: Daily interaction with the director, director of research operations, research coordinators, research faculty, other team members.
University: Occasional to frequent interaction with other departments
External: Occasional to frequent contact with collaborators at University Hospitals, Cleveland Clinic, and with collaborators at collaborating institutions
Students: Contact with graduate and undergraduate students within the Center
Mentor graduate and undergraduate students in the lab especially in the field of clinical pathology
Experience: 3 to 5 years of related experience required.
Education/Licensing: PhD in Biomedical Engineering or related field or MD degree required. Graduate level experience in pathology preferred.
1. Extensive domain knowledge in pathology.
2. Expert knowledge in ImageScope, QuPath for viewing and analyzing pathology images.
3. Professional and effective oral and written communications skills. Must be able to clearly relay information to the Center Director and other Center team members.
4. Effective management skills; ability to lead, train, work with, and elicit cooperation from team members and staff.
5. Ability to problem solve effectively; ability to develop and implement alternative solutions as needed.
6. Ability to learn and apply new ideas, techniques, processes, policies, functions, etc. Must be highly motivated and a self-starter.
7. A willingness to acquire further skills and to train research team members (including students) on these skills.
The working conditions are typical of an office environment and computer rooms. There will be little to no exposure to hazards. The work requires negligible physical exertion, however, limited manual dexterity is required.
In employment, as in education, Case Western Reserve University is committed to Equal Opportunity and Diversity. Women, veterans, members of underrepresented minority groups, and individuals with disabilities are encouraged to apply.
Please send curriculum vitae, a cover letter, and names of 3 references to Katherine Gullett, firstname.lastname@example.org